姓名：田婵

职称：研究员、博士生导师

邮箱：tianchan@bjmu.edu.cn

联系地址：北京大学医学部中心楼909

个人简介

田婵课题组从事生殖遗传、产前诊断等遗传学诊断及科研工作，研究方向包括出生缺陷的发生机制，遗传学诊断新方法研发，生殖障碍的遗传因素研究等。主持国家自然科学基金、科技部重点研发专项课题等多个国家级课题，参编专著六部，科普书一部。发表SCI论文90余篇，其中以第一/责任作者（含共同）在Nucleic Acids Res、IEEE T Med Imaging、Mol Neurobiol等杂志共发表SCI收录论文20余篇，多篇论文被国际教科书《Handbook of Clinical Neurology》引用，授权专利3项并转化。

主要研究方向

研究方向：生殖遗传、产前诊断

代表性研究成果

主要兼职：中国青年科技工作者协会理事，中国遗传学会青年委员，中国妇幼保健协会出生缺陷防治与分子遗传分会委员，《Human Genomics》杂志副主编，《Biomedical and Environmental Sciences》杂志编委，全国青联委员。

主要奖励：获“全国青年岗位能手”，“中央国家机关青年岗位能手”称号，中华预防医学会科学技术奖二等奖，中华医学科技奖三等奖，高等学校科学研究科学技术进步二等奖等。

近5年发表文章：

1. Fang T^#, Yuan PB^#, Gong C, Jiang YP, Yu YZ, Shang WH, Tian C*, Ye AP*. Fast label-free recognition of NRBCs by deep-learning visual object detection and single-cell Raman spectroscopy. Analyst. 2022, 47(9):1961-1967.

2. Zhang Y, An MX, Gong C, Li YY, Wang YT, Lin M, Li R, Tian C. Single-copy Loss of Rho Guanine Nucleotide Exchange Factor 10 (arhgef10) Causes Locomotor Abnormalities in Zebrafish Larvae. Biomed Environ Sci. 2022 Jan 20;35(1):35-44.

3. Chen SY, Jia ZL, Cai M, Ye MJ, Wu DD, Wan T, Zhang BW, Wu PX, Xu YX, Guo YT, Tian C^#, Ma D^#, Ma J^#. SP1-Mediated Upregulation of Long Noncoding RNA ZFAS1 Involved in Non-syndromic Cleft Lip and Palate via Inactivating WNT/β-Catenin Signaling Pathway. Front. Cell Dev. Biol. 2021, 9:66278 (IF=6.682)

4. DeepACEv2: Automated chromosome enumeration in metaphase cell images using deep convolutional neural networks. IEEE T Med Imag. 2020, 39(12):3920-3932 (Article IF=10.040)

5. Tian C*, Deng T*, Zhu XH*, Gong C, Zhao YY, Wei Y, Li R, Xu XF, He MN, Zhang ZW, Cheng J, Ben Willem Mol, Qiao J. Evidence of Compliance With and Effectiveness of Guidelines for Noninvasive Prenatal Testing in China: A Retrospective Study of 189,809 Cases. Sci China Life Sci, 2020 63:319-328（Cover story）

6. Li D, Wang Y, Zhao N, Chang L, Liu P, Tian C^#, Qiao J. A case report and mechanism analysis of a normal phenotype mosaic 47, XXY complicated by paternal iUPD (9) who had a normal PGD result. BMC Med Genet. 2019, 20:172

7. Yuan F*, Jin X*, Li D*, Song Y, Zhang N, Yang X, Wang L, Zhu WG, Tian C^#, Zhao Y^#. ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint. Nucleic Acids Res. 2019, 47:8096-8110 (Article IF=16.973)

8. Xiao L, Luo C, Yu T, Luo Y, Tian C^#, Qiao J^#, Zhao Y^#, DeepACE: Automated Chromosome Enumeration in Metaphase Cell Images Using Deep Convolutional Neural Networks. MICCAI. 2019