姓名:刘明慧

职称：中级

邮箱：2116188044@bjmu.edu.cn

联系地址：北京大学医学部解剖楼235

个人简介：

教育经历：

2012-09 至 2018-06, 北京大学, 医学遗传学, 博士

2007-09 至 2012-07, 河北医科大学, 预防医学, 学士

博士后工作经历：

2019-04 至 2021-04, 北京大学医学部

科研与学术工作经历（博士后工作经历除外）：

2021-05 至 今, 北京大学医学部, 基础医学院, 主管技师

主要研究方向：蛋白质翻译后修饰

代表性研究成果：

(1) Minghui Liu; Zhe Wang; Mengmeng Ren; Xin Yang; Boya Liu; Jianyuan Luo* ; SIRT4 regulates PTEN stability through IDE in response to cellular stresses, FASEB Journal, 2019, 33: 5535- 5547 (期刊论文)

(2) Qi Hao; Shi Xiaoyan; Yu Miao; Liu Boya; Liu Minghui; Luo Jianyuan* ; Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/ PRMT5 transmethylase complex activity, JBC, 2018, 46(293): 17769-17779 (期刊论文)

(3) Zhe Wang; Xin Yang; Cheng Liu; Xin Li; Buyu Zhang; Bo Wang; Yu Zhang; Chen Song; Tianzhuo Zhang; Minghui Liu; Boya Liu; Mengmeng Ren; Hongpeng Jiang; Junhua Zou; Xiaoyun Liu; Hongquan Zhang; Wei-Guo Zhu; Yuxin Yin; Zhang Zhang; Wei Gu; Jianyuan Luo* ; Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A, Molecular Cell, 2019, 74: 1-17 (期刊论文)

(4) Tianzhuo Zhang; Zhe Wang; Minghui Liu; Lu Liu; Xin Yang; Yu Zhang; Juntao Bie; Yutong Li; Mengmeng Ren; Chen Song; Wengong Wang; Hongyu Tan; Jianyuan Luo* ; Acetylation dependent translocation of EWSR1 regulates CHK2 alternative splicing in response to DNA damage, Oncogene, 2022, 41(29): 3694-3704 (期刊论文)

(5) Meiting Li; Jiannan Xiong; Liqian Yang; Jie Huang; Yu Zhang; Minghui Liu; Lina Wang; Jianguo Ji; Ying Zhao; Wei-Guo Zhu; Jianyuan Luo*; Haiying Wang ; Acetylation of p62 regulates base excision repair through interaction with APE1, Cell Reports, 2022, 40(3): 111116- 111116 (期刊论文)