杨玉霞，副教授

E-mail: yangyx@bjmu.edu.cn

解剖楼238A

个人简介：

2007年于中国科学院获博士学位，2009-2010年于美国马萨诸塞大学医学院进行博士后工作，2019-2021年于普渡-印第安纳大学医学院进行访学及博士后工作。曾获北京大学医学部优秀教师；北京大学基础医学院优秀青年教师奖励基金；北京大学基础医学院优秀SCI论文奖；北京大学夜大学优秀教师；北京大学医学部教学管理优秀等奖励。主持过国家自然科学、北京市自然科学及北大医学临床+X等项目。以第一或责任作者发表多篇SCI论文，参编一部英文论著，主编一部中文科普编著。为本科生及研究生讲授临床细胞遗传学及原理、表观遗传等课程。目前在北京大学医学部医学遗传系担任副教授。

主要研究方向：造血发育与血液疾病，细胞遗传

代表性研究成果：

1. Hongxia Chen , Yunpeng Bai , Michihiro Kobayashi , Shiyu Xiao , Sergio Barajas , Wenjie Cai , Sisi Chen , Jinmin Miao , Frederick Nguele Meke , Chonghua Yao , Yuxia Yang , Katherine Strube , Odelia Satchivi , Jianmin Sun , Lars Ronnstrand , James M Croop , H Scott Boswell , Yuzhi Jia , Huiping Liu , Loretta S Li , Jessica K Altman , Elizabeth A Eklund , Madina Sukhanova , Peng Ji, Wei Tong, Hamid Band , Danny T Huang, Leonidas C Platanias , Zhong-Yin Zhang , Yan Liu. PRL2 phosphatase promotes oncogenic KIT signaling in leukemia cells through modulating CBL phosphorylation. Mol Cancer Res. 2023 Sep 27.

2. Yuxia Yang, Wei Fan, Rong Wang, Rui Wang, Wei Gu, Jianyuan Luo. Regulation of Rothmund–Thomson syndrome protein RecQL4 functions in DNA replication by SIRT1-mediated deacetylation. Genome Instability & Disease. 2, pages240–252 (2021).

3. Shi Song, Yuxia Yang^#, Minghui Liu, Boya Liu, Xin Yang, Miao Yu, Hao Qi, Mengmeng Ren, Zhe Wang, Junhua Zou, Feng Li, Xiaojuan Du, Hongquan Zhang, Jianyuan Luo. MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6. Am J Cancer Res. 2018 Jun 1; 8(6):993-1007.

4. Yuxia Yang, Li Wei, Yanju Zhang, Takahide Hayano, Maria del Pilar Pineiro Pereda, Hirofumi Nakaoka, Qiang Li, Isabel Barragan Mallofret, Yuanzhi Lu, Luca Tamagnone, Ituro Inoue, Xiangdong Li, Jianyuan Luo, Ke Zheng, Hua You. Long non-coding RNA p10247, high expressed in breast cancer (lncRNA-BCHE), is correlated with metastasis. Clin Exp Metastasis.2018 Mar; 35(3):109-121.

5. Yuxia Yang, Yanju Zhang, Zhenchuan Miao, Junhua Zou, Jianyuan Luo. MiR-22 inhibits CD34 (+) cell expansion through decreasing β-Catenin in osteoblasts. Hum Gene Ther. 2017 Jan;28(1):135-145.

6. Mengyu Hu,Yuxia Yang*^#,Zhi Ji,Jianyuan Luo.RBM15 functions in Blood diseases. Curr Cancer Drug Targets. 2016; 16(7):579-85.

7. Yang Yuxia, Wang Saifeng, Miao Zhenchuan, Ma Wei, Zhang Yanju, Su Li, Hu Mengyu, Zou Junhua, Yin Yuxin, Luo Jianyuan. MiR-17 promotes expansion and adhesion of human cord blood CD34(+) cells in vitro. Stem Cell Res Ther. 2015 Sep 7;6(1):168.

8. Yang Yuxia, Hu Mengyu, Zhang Yanju, Li H, Miao Zhenchuan. CD29 of human umbilical cord mesenchymal stem cells is required for expansion of CD34 (+) cells. Cell Prolif. 2014 Dec;47(6):596-603.

9. Y.J. Zhang^#, Yuxia Yang*, M.Y. Hu, Q.K. Ni, H.G. Li, and Z.C. Miao. Importance of CD44 on umbilical cord mesenchymal stem cells for expansion of hematopoietic cells. Cell Mol Biol (Noisy-le-grand). 2015 May 8;61(2):18-25.

10. Yi Jingjie, Huang Xiangyang, Yang Yuxia, Zhu Weiguo, Gu Wei, Luo Jianyuan. Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3. J Biol Chem. 2014 Dec 5; 289(49):33878-86

11. Yang Y, Ma W, Wu D, Huang Y, Li H, Zou J, Zhang Y, Feng M, Luo J. MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts. PLoS One. 2013 Jul 25;8(7)

12. Yang Y, Wang S, Zhang Y, Zhu X. Biological effects of RBM15 decreasing on chronic myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2237-44

英文论著：

Mengyu Hu, Qiankun Ni, Yuxia Yang^# and Jianyuan Luo. RNAi-based Gene Therapy for Blood Genetic Diseases. “RNA Interference”(英文版)第九章，InTech出版社。

中文编著：

作为主编之一（两位主编）编写出版了《你身边的遗传奥妙》一书：李惟基，杨玉霞. 中国农业大学出版社。